clinical_trials
[Articles] Empirical tuberculosis treatment in infants living with HIV hospitalised with severe pneumonia in Africa (EMPIRICAL): a multicentre, randomised, open-label, 2 × 2 factorial, controlled superiority trial
Confidence96·multiple reportsImportance98NP-EVT-20261114-3A8FF5D
In contrast to empirical treatment with valganciclovir, there was no evidence that eTB-T was superior to a clinically and microbiologically guided strategy in reducing all-cause mortality among infants with HIV-associated pneumonia. However, the high proportion of infants who eventually initiated tuberculosis treatment during follow-up in the non-eTB-T groups might have reduced the contrast between strategies and attenuated the ability to detect differences in outcomes.
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[Articles] Empirical tuberculosis treatment in infants living with HIV hospitalised with severe pneumonia in Africa (EMPIRICAL): a multicentre, randomised, open-label, 2 × 2 factorial, controlled superiority trial
Sara Domínguez-Rodríguez, Alfredo Tagarro, Cinta Moraleda, W Chris Buck, Hilda Mujuru, Chishala Chabala, Tisungane Mvalo, Pui-Ying Iroh-Tam, Anélsio Cossa, Lola Madrid, Jahit Sacarlal, Alfeu Passanduca, Uneisse Cassia, Stella Langa, Hellen Tukamuhebwa Aanyu, Abner Tagoola, Constantine Mutata, Bwendo Nduna, Elizabeth Nkosi, Lughano Ghambi, Matthew Bates, Sheila Fernández-Luis, Kajal Chhaganlal, Sara Machava, Damalie Nalwanga, Denis Nansera, Mutsa Bwakura-Dangarembizi, Natasha Namuziya, Franklyn Nkongho Egbe, John Tembo, Álvaro Ballesteros, Raoul Moh, Lilit Manukyan, David Lora, Olivier Marcy, Tom G Jacobs, David Burger, Quique Bassat, Valeriane Leroy, Alessandra Nardone, Victor Musiime, Pablo Rojo, Empirical Clinical Trial Group · 11/14/2026, 12:00:00 AM
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