Gut and urogenital microbiomes influence menopausal hormone therapy outcomes

Nature Medicine, Published online: 13 November 2026; doi:10.1038/s41591-026-04789-6 A 6-month study shows that menopausal hormone therapy induces multi-site microbiome remodeling, including rejuvenation of the vaginal microbial community toward a reproductive-age-like state. In turn, baseline gut and vaginal community types affect the clinical response to therapy. Integrating clinical and gut microbiome features predicts rapid symptom remission, providing a blueprint for precision menopausal c