clinical_trials
Domain-alteration chimeras rewire oncogenic complexes in prostate cancer
Confidence95·multiple reportsImportance97NP-EVT-20261111-ED857B0
Nature, Published online: 11 November 2026; doi:10.1038/s41586-026-11262-4 A novel therapeutic modality enforces non-native androgen receptor (AR)–p300/CBP interactions to collapse AR transcriptional programs, producing super-inhibitory, lineage-selective suppression of metastatic prostate cancer and establishing domain-alteration chimeras as a broadly applicable therapeutic strategy leveraging induced proximity.
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Domain-alteration chimeras rewire oncogenic complexes in prostate cancer
Arul M. Chinnaiyan · 11/11/2026, 12:00:00 AM
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