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The molecular basis of replication fork restart via repriming by PRIMPOL
Confidence95·multiple reportsImportance97NP-EVT-20261111-D3564B9
Nature, Published online: 11 November 2026; doi:10.1038/s41586-026-11276-y PRIMPOL is recruited to stalled forks through an interaction with the replicative helicase CDC45–MCM2–7–GINS, facilitating primer handover from PRIMPOL to the high-fidelity polymerase ε, minimizing mutagenic DNA synthesis.
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The molecular basis of replication fork restart via repriming by PRIMPOL
Gheorghe Chistol · 11/11/2026, 12:00:00 AM
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