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UNC13A splice correction rescues synaptic dysfunction induced by TDP-43 loss
Confidence95·multiple reportsImportance97NP-EVT-20261111-C8E86E7
Nature, Published online: 11 November 2026; doi:10.1038/s41586-026-11256-2 TDP-43 loss induces a predegenerative state in which neurons remain structurally intact and suffer a substantial breakdown in synaptic communication; a therapeutic strategy is found that corrects UNC13A cryptic splicing by using splice-switching antisense oligonucleotides.
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UNC13A splice correction rescues synaptic dysfunction induced by TDP-43 loss
Pietro Fratta · 11/11/2026, 12:00:00 AM
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