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clinical_trials

Normalized membrane ratio of TROP2 as a predictor of clinical outcomes with datopotamab deruxtecan in non-small-cell lung cancer

Confidence95·multiple reportsImportance97NP-EVT-20261111-C2F7108

Nature Medicine, Published online: 11 November 2026; doi:10.1038/s41591-026-04716-9 This work developed and validated a computational pathology biomarker—the TROP2 normalized membrane ratio—that quantifies subcellular TROP2 localization and predicts improved progression-free and overall survival with datopotamab deruxtecan in patients with nonsquamous non-small-cell lung cancer lacking actionable genomic alterations.

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Normalized membrane ratio of TROP2 as a predictor of clinical outcomes with datopotamab deruxtecan in non-small-cell lung cancer
Jacob Sands · 11/11/2026, 12:00:00 AM
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