Validation of clinical and preclinical obesity across global cohorts

Nature, Published online: 11 November 2026; doi:10.1038/s41586-026-11237-5 A large-scale data analysis assesses the Lancet Commission’s proposed diagnostic framework for obesity, finding that this framework, in which BMI is combined with other criteria, such as waist circumference and organ function, is more useful than classifications based on BMI alone.