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NRF2 is a mechanosensitive checkpoint for NLRP3 inflammasome activation

Confidence95·multiple reportsImportance97NP-EVT-20261111-6BDF003

Nature, Published online: 11 November 2026; doi:10.1038/s41586-026-11324-7 The stiffness of the extracellular matrix is identified as a pivotal factor that influences activation of the NLRP3 inflammasome in vitro and in vivo.

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NRF2 is a mechanosensitive checkpoint for NLRP3 inflammasome activation
Jonathan C. Kagan · 11/11/2026, 12:00:00 AM
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