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Human replisomes direct a dedicated leading-strand primase for fork restart

Confidence95·multiple reportsImportance97NP-EVT-20261111-57FB1F4

Nature, Published online: 11 November 2026; doi:10.1038/s41586-026-11204-0 Structural and biochemical studies show that the CMG helicase directly recruits PRIMPOL for leading-strand repriming, enabling replication fork restart and limiting post-replicative DNA gaps.

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Human replisomes direct a dedicated leading-strand primase for fork restart
Joseph T. P. Yeeles · 11/11/2026, 12:00:00 AM
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