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Comprehensive mapping of essential-gene interactions in M. tuberculosis

Confidence95·multiple reportsImportance97NP-EVT-20261104-74DA09D

Nature, Published online: 04 November 2026; doi:10.1038/s41586-026-11212-0 A high-throughput CRISPR-interference platform allows the mapping of interactions between essential genes in Mycobacterium tuberculosis, revealing many previously unknown genetic interactions and providing insight into gene function and drug–target relationships that could enable the development of new therapies for tuberculosis.

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Comprehensive mapping of essential-gene interactions in M. tuberculosis
Jeremy M. Rock · 11/4/2026, 12:00:00 AM
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