clinical_trials
This cholesterol drug promised to be a game-changer. Why did it flop in the clinic — and is there still hope?
Confidence95·multiple reportsImportance97NP-EVT-20261103-7C1B753
Nature, Published online: 03 November 2026; doi:10.1038/d41586-026-03504-2 Physicians were excited about several therapies that slash levels of lipoprotein(a) — an important cardiovascular risk factor. One major trial failed to show a benefit, and now scientists are scrambling to work out what that means.
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This cholesterol drug promised to be a game-changer. Why did it flop in the clinic — and is there still hope?
Cassandra Willyard · 11/3/2026, 12:00:00 AM
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