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MCT1-dependent mitochondrial lactate import sustains cardiac metabolism

Confidence95·multiple reportsImportance97NP-EVT-20261028-77B51CA

Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-11182-3 In mouse myocardium, glucose oxidation persists in the absence of the mitochondrial pyruvate carrier, with mitochondrial MCT1 importing lactate into mitochondria and LDHB oxidizing it to pyruvate and NADH, sustaining cardiac energetics and preventing stress-induced heart failure.

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MCT1-dependent mitochondrial lactate import sustains cardiac metabolism
Gregory S. Ducker · 10/28/2026, 12:00:00 AM
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