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GRP75-dependent SIMPA mediates inter-organellar quality control

Confidence95·multiple reportsImportance97NP-EVT-20261021-7FAEA31

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-10733-y Proteotoxic stress drives formation of GRP75-dependent protein aggregates that signal through mitochondria–ER contact sites to activate targeted quality-control pathways, enabling selective clearance of damaged proteins and preserving mitochondrial integrity.

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GRP75-dependent SIMPA mediates inter-organellar quality control
Quan Chen · 10/21/2026, 12:00:00 AM
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