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EGFR-targeted antibody−toxin conjugate in recurrent glioma: a phase 1 trial

Confidence95·multiple reportsImportance97NP-EVT-20261016-132CDDF

Nature Medicine, Published online: 16 October 2026; doi:10.1038/s41591-026-04715-w Results of a phase 1 trial of the antibody−toxin conjugate D2C7-ATC targeting EGFR/EGFRvIII in patients with recurrent malignant glioma show encouraging safety and efficacy signals, with translational analyses of patient samples indicating intratumoral and systemic immune activation.

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EGFR-targeted antibody−toxin conjugate in recurrent glioma: a phase 1 trial
Annick Desjardins · 10/16/2026, 12:00:00 AM
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