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De novo design of cysteine proteases

Confidence95·multiple reportsImportance97NP-EVT-20261014-AC41BF0

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11143-w De novo-designed enzymes use an activated cysteine nucleophile to hydrolyse polypeptide backbones in a sequence-dependent manner.

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De novo design of cysteine proteases
David Baker · 10/14/2026, 12:00:00 AM
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