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Engineered TYK2 dependence enables myeloid-selective IL-10 receptor agonism

Confidence95·multiple reportsImportance97NP-EVT-20261014-71BD859

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11176-1 A tetravalent nanobody-based myeloid-selective IL-10 receptor agonist recapitulates IL-10’s potent suppression of monocytes, macrophages and dendritic cells while avoiding stimulation of T cells.

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Engineered TYK2 dependence enables myeloid-selective IL-10 receptor agonism
Tangsheng Yi · 10/14/2026, 12:00:00 AM
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